VitD supplementation is essential in patients at risk of fracture and/or vitD deficiency. Patients at risk of fracture with insufficient dietary intake and absorption could benefit from calcium supplementation, but it needs to be customized, taking into account possible side-effects and degree of adherence. Ca supplementation alone is not recommended for fracture prevention in the general postmenopausal population. This narrative review summarizes the most recent data on Ca, vitD, vitK2 and Mg supplementation and age-related bone and muscle loss. Other supplements like vitamin K2 (VitK2) and magnesium (Mg) could contribute to the maintenance of skeletal health. Supplementation with calcium (Ca) and/or vitamin D (vitD) is key to the management of osteoporosis.
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